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A reconstruction of a late Neanderthal from El Salt.
A reconstruction of a late Neanderthal from El Salt, southeastern Spain. Some of the last Neanderthals may have lived in the Iberian peninsula. Our closest human relatives may have died out thanks to a combination of factors, including isolation, inbreeding and competition from modern humans, emerging research suggests. | Credit: Fabio Fogliazza
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About 37,000 years ago, Neanderthals clustered in small groups in what is now southern Spain. Their lives may have been transformed by the eruption of the Phlegraean Fields in Italy a few thousand years earlier, when the caldera’s massive explosion disrupted food chains across the Mediterranean region.
They may have gone about their daily life: Crafting stone tools, eating birds and mushrooms, engraving symbols on rocks, and creating jewelry out of feathers and shells.
They likely never realized they were among the last of their kind.
But the story of their extinction actually begins tens of thousands of years earlier, when the Neanderthals became isolated and dispersed, eventually ending nearly half a million years of successful existence in some of the most forbidding regions of Eurasia.
By 34,000 years ago, our closest relatives had effectively gone extinct. But because modern humans and Neanderthals overlapped in time and space for thousands of years, archaeologists have long wondered whether our species wiped out our closest relatives. This may have occurred directly, such as through violence and warfare, or indirectly, through disease or competition for resources.
Now, researchers are solving the mystery of how the Neanderthals died out — and what role our species played in their demise.
Reconstruction of burial of Neanderthal Man (Homo sapiens neanderthalensis) at La Chapelle-aux-Saints, France.
A reconstruction of a Neanderthal burial unearthed in the early 20th century in Chapelle-aux-Saints, France. The skeleton found there, which had a deformed spine, inspired an early depiction of Neanderthals as «knuckle-dragging brutes.» | Credit: DEA / A. DAGLI ORTI/De Agostini via Getty Images
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«I think the fact is, we do know what happened to Neanderthals, and it is complex,» Shara Bailey, a biological anthropologist at New York University, told Live Science.
Decades of research has revealed a complex picture: A perfect storm of factors — including competition among Neanderthal groups, inbreeding and, yes, modern humans — helped erase our closest relatives from the planet.
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The rise and demise of our closest human relatives
The modern story of Neanderthals began in 1856, when quarry workers found a strange-looking, not-quite-human skull in Germany’s Neander Valley.
Archaeologists gave the skull a new species name: Homo neanderthalensis. And in the early decades after the discovery, researchers assumed the creatures were knuckle-dragging brutes. This depiction was based on a flawed reconstruction of a skeleton of an old Neanderthal man, whose spine was deformed by arthritis, found at La Chapelle-aux-Saints in France.
Now, more than 150 years of archaeological and genetic evidence makes it clear that these early human relatives were much more advanced than we originally thought. Neanderthals crafted sophisticated tools, may have made art, decorated their bodies, buried their dead, and had advanced communication abilities, albeit a more primitive kind of language than modern humans used. What’s more, they survived for hundreds of thousands of years in the hostile climates of Northern Europe and Siberia.
Before they met in Eurasia, Neanderthals and modern humans last shared an ancestor in the Middle Pleistocene epoch, between 600,000 and 800,000 years ago. Modern humans and Neanderthals evolved separately; Neanderthals adapted to cold climates with sturdier bodies, larger faces and different metabolic processes than the taller, thinner Homo sapiens. Neanderthals evolved in Eurasia about 400,000 years ago, and H. sapiens arrived significantly later, evolving in Africa 300,000 years ago and settling in Europe between about 55,000 and 45,000 years ago.
Based on archaeological evidence from sites from Russia to the Iberian Peninsula, Neanderthals and modern humans likely overlapped for at least 2,600 years — and perhaps as long as 7,000 years — in Europe. That overlap occurred during a bleak period in Neanderthal history that ended with their downfall — raising the question of whether modern humans were responsible for killing them off.
But the story of Neanderthal life — and extinction — is one of regional variation, said Tom Higham, an archaeological scientist at the University of Vienna.
«In some areas, for example, we see that humans arrive to empty spaces in Europe where there aren’t any Neanderthals anymore, seemingly,» Higham told Live Science. «And in other places, we see that there’s probably an overlap that happens … we know that people are interbreeding.»
The first empirical proof of that interbreeding was found in 2010, when a Neanderthal genome was sequenced. Since then, genetic analysis has shown that Neanderthals and modern humans shared much more than a geographic area — we regularly exchanged DNA back and forth, meaning there is a bit of Neanderthal in every modern human population studied to date.Already on the brink
When modern humans and Neanderthals met tens of thousands of years ago, the latter were probably already in trouble. Genetic studies suggest that Neanderthals had lower genetic diversity and smaller group sizes than modern humans, hinting at a potential reason for Neanderthals’ demise.
«Genetically, one big clue that we get is this idea of heterozygosity,» Omer Gokcumen, an evolutionary genomicist at the University at Buffalo, told Live Science. An individual receives two copies, or alleles, of a gene from each parent. Individuals are «heterozygous» for a given gene if they inherit a different allele from each parent. In Neanderthals’ small communities, which contained fewer than 20 adults in each group, more inbreeding occurred. That meant fewer of them inherited different versions of a gene from each parent and, therefore, had low heterozygosity.
«Neanderthals may have suffered for that — what they call a mutational burden,» Gokcumen said. Genetic research suggests Neanderthals had many problematic mutations that likely affected their survival, including a rare blood type. «Because of their small population size, they couldn’t actually breed these bad alleles out, and their kids may actually be sickly at the end,» Gokcumen said.
Any population of animals survives into the future through successful reproduction and rearing of offspring. Researchers estimating the mortality rates of Neanderthal infants have found that a decrease of even 1.5% in the survivorship of these children could result in population extinction within 2,000 years, April Nowell, a Paleolithic archaeologist at the University of Victoria in British Columbia, told Live Science.
A partially reconstructed Neanderthal skull found in St. Césaire, France.
Archaeologists once thought that warfare or conflict between modern humans and Neanderthals helped wipe out our closest human ancestors. And there is some evidence that Neanderthal were victims of interpersonal violence. For instance, a Neanderthal skull found in St. Césaire, France, had a fracture wound inflicted with a sharp implement. But there is no evidence that modern humans inflicted that wound, or even that they occupied the same cave. | Credit: Raphael GAILLARDE/Gamma-Rapho via Getty Images
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«There doesn’t have to be very much going on to really have a dramatic impact on the viability of your population,» Nowell said.
So while Neanderthal populations began decreasing until they became small, isolated groups without the social support necessary to care for their increasingly sickly babies, modern human groups quickly expanded through Europe.
Humans and Neanderthals: A bad mix?
During two periods across Eurasia 135,000 and 100,000 years ago, Neanderthal populations nearly died out. But they bounced back, powering through these cold snaps and the resulting changes to their landscapes.
«Neanderthals survived all of these hardships,» Bailey said. «It wasn’t until they had the additional pressure of Homo sapiens that they eventually went extinct.»
Given the overlap in time and space, researchers used to think modern humans played a direct role in Neanderthals’ demise via warfare or novel diseases.
There is some evidence of violence on Neanderthal skeletons. A young adult male from St. Césaire, France, dating to around 40,000 years ago suffered a fracture to the top of his head made with a sharp implement, and an older male found in Shanidar Cave, Iraq, dating to around 50,000 years ago had a partially healed stab wound on his left rib. But there’s no way to say whether modern humans or other Neanderthals inflicted this violence. Unless archaeologists find a site where Neanderthals are clearly the victims of a massacre inflicted by modern humans, it will be impossible to conclude that modern-human violence was a major cause of Neanderthals’ extinction.
Neurons (yellow) spread out among other cells called astrocytes (blue).
Neurons (shown in yellow) in Neanderthal-inspired brain organoids, or 3D, self-sustaining brain tissue in a dish, fire more chaotically and develop fewer interconnections than do modern human «mini-brains.» This may have made Neanderthals less nimble thinkers. This, in turn, may have meant they were less skilled hunters and foragers than modern humans were. | Credit: Alysson Muotri Lab/UCSD
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Nor is there genetic evidence that modern humans’ diseases killed off the Neanderthals, though we do share many immune-related genes. For instance, we inherited Neanderthal genes that make us susceptible to autoimmune disorders such as lupus and Crohn’s disease as well as to severe COVID-19. Future genetic analyses may reveal the potential role of disease in Neanderthals’ demise, Gokcumen said.
Winners and losers in the fight for resources
But warfare and pestilence aren’t the only possible ways modern humans may have led to Neanderthals’ vanishing. When two groups come together, competition can lead to tragic outcomes.
Neanderthal artifacts, such as pendants, etchings and fire-making kits, show that Neanderthals were intelligent. But new research suggests there are significant differences between H. sapiens and Neanderthal brains: Modern humans have more neurons in brain regions key to higher-level thinking, and their neurons are more connected — meaning modern humans were likely more capable of thinking quickly. Combined with Neanderthals’ greater difficulty in processing language, this could mean modern humans had an advantage in key tasks, Nowell said, such as hunting and foraging for food.
And while Neanderthals’ extremely isolated groups may have had a biological disadvantage, they probably had a cultural one, too.
«Ideas can spread more easily when you have bigger populations and other people can build on them,» Bailey said. But given Neanderthals’ disparate populations, «their artistic or cultural kinds of innovations might not have progressed the way we see in much larger populations that have a lot of interactions with people,» she said.
Although Neanderthals created tools that were very sophisticated for the time, we haven’t found any unambiguous long-range weapons made by Neanderthals. Modern humans’ ability to devise projectile weapons, by contrast, may have given us a survival advantage.